Tenvir EM is a combination medicine containing Tenofovir disoproxil fumarate and emtricitabine as the active ingredients. It is used as a part of a regimen of antiretroviral medications to treat HIV-1 in adults. The medication is taken along with safer sex practices to reduce the risk of sexually acquired HIV-1 in adults aged over 18 years at high risk.
The combination drug comes in the tablet form, and these tablets are used in combination with other medications that have a different working mechanism to treat HIV patients. Such patients have either already received treatment with other HIV medication or are undergoing first-line treatment. Both the antiretroviral agents are effective against RNA viruses such as Human Immunodeficiency Virus (HIV).
Side effects associated with Tenvir EM
Along with the benefits, like other pharmaceutical agents, Tenvir EM too comes with side effects. The most commonly reported side effects reported with the active ingredient Tenofovir disoproxil fumarate in HIV-1 infected patients include diarrhea, pain, asthenia, nausea, rash, and headache. Clinical trials were conducted in order to check the range of different side effects in people taking this combination medicine. During the controlled clinical trial, the most common side effects associated with this antiretroviral agent have included mild to moderate gastrointestinal issues such as vomiting, diarrhea, nausea, and flatulence.
In patients with chronic hepatitis B virus (HBV) infection and hepatic insufficiency side effects included diarrhea, fatigue, pain, skin rash, back pain, headache, nausea, dizziness, abdominal pain, and nasopharyngitis were reported with Tenofovir disoproxil fumarate.
Gastrointestinal issues- The gastrointestinal events associated with the combination drug include nausea, vomiting, abdominal pain most commonly occurred in patients who are suffering from HBV and decompensated liver disease. Pancreatitis has also been reported during postmarketing experience.
Very common side effects are diarrhea, vomiting, nausea, and abdominal pain. While pancreatitis and elevated serum lipase are some uncommon side effects of the medicine.
Very common ones include rash events such as pruritus, exfoliative rash, macular rash, vesicular rash, urticaria, maculopapular rash. The commonly reported dermatological issues were sweating.
Nervous system disorders-
Very common side effects associated with Tenvir EM include dizziness and headache, while the common ones include peripheral neuropathy (a medical condition that affects the nerves, impairing sensation movement and or organ function). Dizziness was also reported in patients with chronic HBV and decompensated hepatic impairment.
- Lactic acidosis and severe hepatomegaly (enlarged liver) with steatosis also called fatty liver have been reported with the use of this medication.
- Very common side effects that are associated with the use of Tenvir EM include hypophosphatemia, elevated fasting cholesterol, elevated triglycerides
- The common ones are anorexia, elevated alkaline, increased fasting triglycerides. While the rare side effects include lactic acidosis and hypokalemia (deficiency of potassium in the blood).
Insomnia was reported in patients with chronic HBV and decompensated hepatic impairment. Depression, insomnia, abnormal dreams, and anxiety were commonly reported side effects of the antiretroviral drug.
Respiratory system disorders-
- Common- infection of the upper respiratory tract, pharyngolaryngeal pain, pneumonia, nasopharyngitis (commonly called as cold)
- Uncommon- nasal congestion
- Common: back pain, arthralgia (joint pain)
- Uncommon ones: muscular weakness
- Rare one- myopathy (a disorder of muscle tissue)
Severe acute exacerbations of hepatitis have been reported in patients with hepatitis B after stopping the HIV treatment with Tenvir EM.
Common: Increased creatinine levels
The rare ones include acute renal failure, renal failure, nephrogenic diabetes insipidus, acute tubular necrosis.
- Common- glycosuria (excretion of glucose into the urine), hematuria (Presence of blood in urine)
- Uncommon- decreased urine volume
Allergic reaction such as angioedema was also reported in the clinical trials.
Tenvir EM is an anti-viral medication, especially discovered for the treatment of patients who are suffering from human immunodeficiency virus (HIV). It is a combination drug which includes two antiretroviral agents, namely Tenofovir disoproxil fumarate and Emtricitabine.
How the combination drug works?
The combination medicine comes in the form of a tablet. This antiviral tablet works by inhibiting the action of the viral-specific enzyme reverse transcriptase, which is required by the virus to reproduce. The medication is helpful in preventing the multiplication of HIV in the patient’s body, thereby stopping HIV from producing new viruses. Patients who have been using this combination drug should be aware of the fact that these tablets do not cure HIV or AIDS but only used to slow down the reproduction process of HIV within the patient’s body. The drug is also effective in preventing or spreading of this infection to others.
Tenvir EM dosage
A treatment plan for HIV requires at least three different antiviral agents to fight against the virus. Tenvir EM contains two different medicines so will always need to be taken along with a with another anti-retroviral agent to reduce slow down the progression of the disease. Your healthcare specialist will provide you with a complete treatment plan including dosages.
Before beginning treatment with the antiretroviral drug, make sure that your health care provider is aware of a health condition called hepatitis B, nay renal impairment, or any bone abnormalities. A patient who is prescribed this drug must take this medicine daily for as long as advised by your health specialist. Also, do not stop the treatment yourself without discussing with your healthcare provider.
For most people, for slowing down the process of replication of HIV in the body, a single pill is taken orally with a glass of water, at the same time daily before or after consuming food. Since this antiviral medication is said to cause renal insufficiency with a creatinine clearance of 30 to 49ml/min should only consume one tablet every 48 hours. Patients with a creatinine clearance of less than 30 ml/min should avoid taking Tenvir EM at all. One can discuss with his/her health care specialist for more information.
If you are looking to buy Tenvir EM to slow down the replication of the virus in the body, then buying from an online pharmacy is a great way to save a considerable amount of money. One can buy Tenvir EM online at an affordable rate from buyviagrasofttabs.info. Here, the combination drug comes in the package of 30, 60, and 90 tablets. Each tablet delivers 300 mg of Tenofovir disoproxil fumarate and 200 mg of Emtricitabine in HIV patient’s body. Store the tablets at room temperature and avoid using it if the seal on bottle is broken or missing.
Side effects associated with Tenvir EM
Most commonly reported side effects of Tenvir Tenofovir and Emtricitabine include nausea, dizziness, trouble sleeping, abnormal dreams, fatigue, depression, constipation, and stomach pain. Lactic acidosis is a more serious and a less common side effect of this antiviral medicine. Lactic acidosis occurs when there is excess lactic acid in a patient’s blood due to living damage, which results in liver failure or renal failure.
Tenvir EM Should not be given to patients who are lactose tolerant or allergic to any of the ingredients of the medication. Furthermore, a patient should disclose if he/she has conditions like obesity, a history of kidney problems, hepatitis or alcohol abuse to make sure the correct dose adjustment is made to your treatment regimen. A patient is instructed to follow his/her health specialist’s direction carefully while taking medicine.
Acyclovir cream is specially formulated for the treatment of cold sores. It is an antiviral treatment that promotes healing.
Acyclovir Cream Uses
The cream form of Acyclovir is made to treat cold sores (an infection) caused by herpes virus/. You must be at least 16 years of age to buy this medication from a medical store or an online pharmacy. This antiviral drug for topical application is suitable for adults and children. Acyclovir is an active ingredient which is helpful n preventing forming cold sores near, eyes, nose, or lips. However, the acyclovir medication cannot prevent future outbreaks from occurring. It is useful in treating cold sores by fighting against the infection and keeping the herpes virus from reproducing or spreading in other parts of the body. A user must be very careful while using this topical agent and should take the only small amount of the cream. A healthcare specialist can also prescribe this medication for treating other viral skin infections.
Cold Sores and Acyclovir
The cream form of acyclovir is different from the ointment form. Cold sores are referred to as herpes labialis (medical term). These are a type of infection that is caused by herpes simplex virus type 1 (HSV-1). This form of herpes infections can also call as fever blisters, usually, develops on lips or mouth. These are very common in people with cold sores. Remember that cold sores can be highly contagious; they can spread or transfer in other people easily. According to clinical trials, the condition is more commonly reported in people who have never had a cold sore in his/her lifetime. The topical form is clinically approved for the treatment of adults and as well as adolescents age 12 years and older.
Mechanism of action of Acyclovir Cream
Herpes simplex virus (HSV-1) is responsible for causing the contagious infection cold sores. The topical application of Acyclovir is helpful for the body to fight the infection. The cream form prevents the HSV-1 from multiplying and spreading in the body. However, it is important to note that the virus never goes away; rather the medication helps make it remain inactive in certain nerve cells of the body, waiting to become active again and cause harm to the body. The topical treatment is not helpful in preventing future outbreaks of cold sore of herpes labialis.
Price of Acyclovir
Acyclovir cream is not an expensive medication to treat and prevent infections caused by HSV-1. The topical treatment is more popular than other medications available for herpes infections. Its availability in the market is in both generic and brand form. Acyclovir cream is covered by most medical store and online pharmacy, but some pharmacy product prices are lower and affordable. One of such online pharmacy is premimrxdrugs.com, where you can get your antiviral drug at the lowest price as compared to other online or local medical stores. So, order Acyclovir cream or other antiviral medications online at an absolute lowest rate.
Cold sore is a common condition affecting almost 90% of adults by the age of 50 as per the National Institute of Health. Cold sores are the blister around the lips, cheeks, and nostrils and are caused by Herpes Simplex Virus type 1 and type 2. It is a contagious infection which can travel from one person to another person when comes in direct contact. Most of the cases, the virus remains in dormant state and gets activated by triggers like fever or infection.
Cold sores are recurrent in nature and have a horrible tingling sensation. Is there any solution to extremely painful and damaging cold sores? By far the most effective treatment option available in the market is a topical form of Acyclovir for cold sores. The medicine is indicated for the suppression and prevention of recurrent cold sores in immunocompromised patients in adolescents of age 12 years and older.
Acyclovir treating cold sores
A synthetic nucleoside alternative which is active against herpes simplex virus causing infection of cold sores. It is antiviral in nature and acts against the causative virus and reduces the severity and length of their outbreaks.
Acyclovir Cream can strongly bond with the enzyme thymidine kinase which is encoded by the HSV virus. The medicine when taken gets converted into acyclovir triphosphate which competitively blocks the enzyme viral DNA polymerase and gets entered into viral DNA. It blocks the process of viral DNA synthesis, thus reduces the outbreak of the virus. It is highly selective in nature and has low cytotoxicity.
Acyclovir Dosage for Cold Sores
It is available in the topical dosage form and contains 50 mg of Acyclovir as an active ingredient. It is available with Acivir Cream 5%. The therapy is initiated when lesions start appearing. Applying medicine as early as you discover any lesion will always give the best results. The dose is usually recommended 5 times per day for consecutive 4 days. The dose is same for the adolescents 12 years of age and older as in the adults. The best and effective dose is always recommended by the doctor depending on the severity of the condition.
- Wash your hands before you apply the cream
- Clean and dry the skin with towel
- Apply the cream to cover the cold sore and rub it gently until it gets absorbed
- Repeat the procedure 5 times or as per the doctor recommendation
- Wash your hands after applying cream so that cream should not be left on it
- Ensure the cap on the tube is tightly closed
- Store the cream at room temperature and keep them out of the reach of children
Acyclovir is intended for topical use only. Avoid applying it near the eyes, inside the mouth or nose. It should be applied on the affected and external areas of lips and face. In case of any hypersensitive reaction consult your doctor. Till date, acyclovir cream is one of the most promising medicines for the reduction of lesion outbreaks on the skin.
Acyclovir is proven at combating herpes symptoms and is available in the form of 400 mg dispersible tablets. It can be consumed for both long and short term period.
Uses of Acyclovir 400mg
Acyclovir 400mg is a prescription medicine clinically approved by the Food and Drug administration for the treatment and prevention of recurrence of herpes simplex virus infection including genital herpes and for the treatment of varicella zoster virus including shingles and chicken pox. It is also approved for people with weak immune system or immunocompromised patients. The medication doesn’t cure herpes infections. The virus stays in your body for a long time and causes symptoms again later.
Acyclovir 400mg falls into the category of antiviral, which works in a similar way. It exerts its mode of action by lowering the ability of the herpes virus to multiply in your body. This action is helpful in treating the symptoms of your infections. However, this antiviral medication does not cure herpes infections. The infection caused by a virus includes shingles, cold sores, genital herpes, or chickenpox. Even with Acyclovir 400mg, the virus may still live inside your body. Your symptoms of infections may recur even after the current infection disappears.
Side Effects of Acyclovir 400mg
The antiviral medication does not cause drowsiness, but it can give rise to other problems. These problems are often referred to the side effects of the medicine. Some of the more commonly reported side effects of dispersible oral tablets are stated below:
All these side effects are mild in nature does not cause serious complications. However, some people may also experience serious side effects associated with the medication. In such cases, it is advisable to inform health care provider and inform about the life threatening symptoms. Some of these serious side effects that an individual taking Acyclovir 400mg may experience are as follows:
- Unusual changes in your behaviour and blood. Symptoms may include:
- Aggressive behaviour
- Trouble speaking
- Unsteady or shaky movements
- Hepatic impairment
- Muscle pain
- Fatigue which indicates the decrease in red blood cells
- Skin reactions including hives, hair loss, breaking or loosening of skin, Stevens-Johnson syndrome, rash
- Symptoms of kidney failure include blood in the urine, pain in the side and back
- Changes in your vision
- Symptoms of an allergic reaction including rash, swelling of your throat or tongue, difficulty breathing, hives
Drug interaction takes place when a drug changes the way another drugs works. This can prevent the medication from working well. To avoid any drug interaction, your health care specialist should manage all of your medications carefully. Drugs interact differently in each person, therefore, be sure, to inform your health care provider about all the medications including supplements, vitamins, and other herbal products. You can discuss with your health care provider, about how your antiviral medication might interact with something else you are taking.
Acyclovir is an antiviral drug, which is highly active against herpes simplex virus type I and II and varicella zoster virus.
Acyclovir –An introduction
The antiviral drug falls into the category of drugs known as antivirals. This medicine has been formulated to treat and prevent genital herpes. It is also useful for the acute treatment of herpes zoster and varicella. Herpes virus is responsible for causing all these infections. Acyclovir helps in healing shingles and chickenpox by stopping the virus from reproducing and spreading to other parts of the body. The drug is produced in several different forms and all are approved for treating infections that are caused by the herpes virus. Your health care specialist will suggest you the best form according to your condition. After evaluating you and determine your health condition, your health care professional will prescribe the dose that will best suit you.
About Cold Sores
Cold sores are common infections in children and adults caused by the herpes virus. There are two types of herpes virus namely HSV type I and HSV type II. HSV type II is usually found in the mouth while HSV II develops in the genitals. Cold sores are blisters that occur on and around the lips. They are painful sores and are also called fever blisters. There is no cure for the problem, but the condition can be prevented by using effective antiviral medications. One of the most effective medications that work against herpes virus is Acyclovir.
Acyclovir for Herpes labialis) cold sores
For the treatment of Herpes labialis or cold sores, it is recommended to use the cream form of the medication. It is suggested to apply the cream topically five times daily for four days. It is always best to start applying Acyclovir topically at the time the first symptoms have started. During the treatment, it is important to assess lesions and on a regular basis. Start the treatment as soon as possible just after herpes simplex symptoms develop and within a day of a herpes zoster outbreak.
Note that the additional use of over the counter creams or ointments may delay healing and cause spreading of lesions. The antiviral medication is not a cure for herpes viruses. The virus will remain in the ganglia, and this medication will prevent the multiplication and spreading of the virus to other parts of the body.
Effect of other drugs on Acyclovir
The antiviral drug can harm your kidneys. This effect might increase when you use certain another drug during the Acyclovir treatment. Such drugs include probenecid, injected antibiotics, drugs to treat bowel disorders, Arthritis medications, other antiviral agents, etc. There are possibilities that other drugs can interact with your antiviral topical agent. Therefore, it is important to inform your health care provider about all the topical and oral medications that you are using at the time of Acyclovir.