What is the Active Ingredient of Champix and its Working Mechanism

23 Jun
2017
By Marie

Champix is a brand of anti-smoking tablets containing the active ingredient Varenicline. It can be purchased only with a health care specialist’s prescription. Varenicline is a quit smoking drug approved by the Food and Drug Administration. It has the ability to reduce withdrawal symptoms to help people overcome the need to smoke. It is believed that Varenicline works best to change habits so that you can live without nicotine. The active component is considered as the second line treatment for smoking cessation and is only suitable for those people who have failed an appropriate trial of bupropion, nicotine replacement therapy, or combination treatment within the past year.

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Varenicline, the active component of the product adheres to these receptors and stimulate their receptor-mediated activities at a remarkably lower level than nicotine, as a result of that reduces cravings and nicotine withdrawal symptoms. The pharmaceutical drug simultaneously acts by preventing nicotine binding to these receptors, which block the stimulation of the central nervous system (CNS) mesolimbic dopamine system and the reinforcing effects of continued nicotine use. Consequently, if a patient smoke during the treatment, Varenicline is capable enough to reduce the feeling of pleasure associated with smoking.

Dosage Instructions

Patients are advised to begin taking Varenicline seven days before their target quit smoking date. The 0.5 mg dose of the medicine should be taken once a day for the first to the third days, 0.5 mg two times a day for the fourth to seven days, and 1 mg dose twice daily after that. If you are not able to tolerate the adverse effects than your health care specialist may adjust your dose. Each dose should be consumed after eating food with a glass full of water.

Patients should continue the varenicline treatment for 12 weeks. Patients who have successfully stop smoking after a period of 12 weeks can continue taking the tablets for an additional 12 weeks treatment to prevent a relapse. Whereas, those who have failed to quit smoking after this period should be encouraged to restart the course after factors behind relapsing have been identified and addressed.  Consult your physician in advance before starting Champix course.

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